HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → 1-(3,5-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| Edukt | 3,5-Difluoroaniline | HCID 96595 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 1-(3,5-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid | HCID 24689209 | 48% |
Reaktionsschritte
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 3,5-difluoroaniline (0.575 g; 4.36 mmol) in ethanol (3 mL). 1-(3,5-difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid 0.167 g (48%) was obtained as a white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09434722B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-6747e784b02f4e8eadb693597e86eadd |
| Quellennotiz | uspto-grants-2016_09 |