Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 4,6-Dimethylpyridin-3-amine | HCID 7060669 | — |
| Edukt | 4-((3,5-Dimethylisoxazol-4-yl)methoxy)benzene-1-sulfonyl chloride | HCID 16490702 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | HCID 117925704 | HCID 117925704 | 97,7% |
Reaktionsschritte
4-{[(3,5-dimethyl-4-isoxazolyl)methyl]oxy}benzenesulfonyl chloride (247 mg, 0.819 mmol) was added to a solution of triethylamine (0.114 mL, 0.819 mmol) and 4,6-dimethyl-3-pyridinamine (100 mg, 0.819 mmol) in dichloromethane (1 mL). The mixture was heated at 70° C. for 2 hours. To the mixture was added water (5 mL) then the organic layer separated and purified by silica (Si) chromatography (100% ethyl acetate). The relevant fractions were combined and concentrated to give the title product (310 mg) as a yellow solid. LCMS (2 min, formic) Rt 0.63 mins, m/z (ES+) 388 (M+H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US09242972B2 |
|---|
| Quelldatensatz | uspto-grants-2016_01 |
|---|
| ORD ID | ord-96c062883cc0451e927ad0e750dae28d |
|---|
| Quellennotiz | uspto-grants-2016_01 |
|---|
