HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzeneacetonitrile, 3-fluoro- → 5-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-(3-fluoro-phenyl)-benzo[c]isoxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzeneacetonitrile, 3-fluoro- | HCID 68145 | — |
| Edukt | 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole | HCID 90033224 | — |
| Produkt | 5-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-(3-fluoro-phenyl)-benzo[c]isoxazole | HCID 73053296 | — |
Reaktionsschritte
The title compound, light yellow solid (85 mg, 65%), MS (ISP) m/z=392.2 [(M+H)+], mp 165° C., was prepared in accordance with the general method of example 1 from 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate I) (100 mg, 353 μmol) and commercially available 2-(3-fluoro-phenyl)-acetonitrile.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09440962B2 |
| Quelldatensatz | uspto-grants-2016_09 |
| ORD ID | ord-f42fe945cc5d4225871be20837cb4799 |
| Quellennotiz | uspto-grants-2016_09 |