HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Aminothiazole → 1-(1-Methylethoxy)-2-nitrobenzene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Aminothiazole | HCID 2155 | — |
| Edukt | Isopropanol | HCID 3776 | — |
| Edukt | 2-(1-Methylethoxy)benzenamine | HCID 34436 | — |
| Edukt | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Produkt | 1-(1-Methylethoxy)-2-nitrobenzene | HCID 197180 | 70% |
| Produkt | N-(2-Isopropoxyphenyl)-N'-thiazolylurea | HCID 47363733 | 60% |
Reaktionsschritte
2-(Isopropoxy)-1-nitrobenzene (317 mg, 70%) was prepared from isopropyl alcohol (0.24 ml, 3.0 mmol) and 1-fluoro-2-nitrobenzene (0.36 g, 2.5 mmol) following the general procedure G. This was reduced to 2-(isopropoxy)aniline (198 mg, 75%) following general procedure B. N-(2-Isopropoxyphenyl)-N′-thiazolylurea (218 mg, 60%) was prepared from 2-(isopropoxy)aniline (198 mg, 01.3 mmol) and 2-aminothiazole (150 mg, 1.5 mmol) following the general procedure D.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07897628B2 |
| Quelldatensatz | uspto-grants-2011_03 |
| ORD ID | ord-05e2bb222c9d4080987aa2ec97d74d5c |
| Quellennotiz | uspto-grants-2011_03 |