HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
18-Crown-6 → 2-Benzenesulfonylmethyl-benzooxazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 18-Crown-6 | HCID 28557 | — |
| Edukt | Benzenesulfinic acid, sodium salt | HCID 2723840 | — |
| Edukt | 2-(Bromomethyl)benzo[d]oxazole | HCID 12745944 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 2-Benzenesulfonylmethyl-benzooxazole | HCID 12475398 | 70% |
Reaktionsschritte
To 9.1 g (0.043 mol) of 2-bromomethyl-benzooxazole in CH3CN (300 mL) were added 7.39 g (0.045 mol, 1.05 eq) of benzenesulfinic acid sodium salt and 2.27 g (8.6 mmol, 0.2 eq) of 18-crown-6. Stirring was continued overnight, solvent evaporated and a column chromatography afforded 8.1 g (70%) of 2-benzenesulfonylmethyl-benzooxazole as a white solid, MS: 274 (H+). (Y. Nagao, S. Yamada, E. Fujita, Tet. Lett., 1983, 24, 2291)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07906546B2 |
| Quelldatensatz | uspto-grants-2011_03 |
| ORD ID | ord-c29c9a0c22224811a7955def82770b32 |
| Quellennotiz | uspto-grants-2011_03 |