HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(S)-1-Phenyl-3-propanolamine → (S)-{4-[4-(3-Hydroxy-1-phenyl-propylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (S)-1-Phenyl-3-propanolamine | HCID 2734520 | — |
| Edukt | 4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid | HCID 59376892 | — |
| Produkt | (S)-{4-[4-(3-Hydroxy-1-phenyl-propylcarbamoyl)-2-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenyl}-carbamic acid tert-butyl ester | HCID 67040426 | 81% |
Reaktionsschritte
According to the procedure in Example 385F, the title compound was prepared using 4-(4-tert-butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid (prepared in Example 385E) and (S)-3-amino-3-phenylpropan-1-ol: yield 81%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07910595B2 |
| Quelldatensatz | uspto-grants-2011_03 |
| ORD ID | ord-b265cd3e1f6b4d428139e0a7c5f6974c |
| Quellennotiz | uspto-grants-2011_03 |