HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(2-Hydroxyethyl)piperazine → (S)-N-[{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| Edukt | N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide | HCID 76585264 | — |
| Produkt | (S)-N-[{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide | HCID 57657889 | — |
Reaktionsschritte
In a manner similar to that described for Example 508, N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide and 1-piperazineethanol were converted to the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07915443B2 |
| Quelldatensatz | uspto-grants-2011_03 |
| ORD ID | ord-f53de5b0781447f6b9bd3b77abcb10bc |
| Quellennotiz | uspto-grants-2011_03 |