HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Iodine → 2-(2-Morpholin-4-yl-ethyl)-6-phenyl-isothiazolo[5,4-d)pyrimidin-3-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Iodine | HCID 807 | — |
| Edukt | 4-Mercapto-2-phenyl-pyrimidine-5-carboxylic acid (2-morpholin-4-yl-ethyl)-amide | HCID 178418292 | — |
| Produkt | 2-(2-Morpholin-4-yl-ethyl)-6-phenyl-isothiazolo[5,4-d)pyrimidin-3-one | HCID 23287882 | 60,8% |
Reaktionsschritte
Using the procedure of Example 20, 2.0 g (5.81 mmol) of 4-mercapto-2-phenyl-pyrimidine-5-carboxylic acid (2-morpholin-4-yl-ethyl)-amide were treated with 1.47 g (5.81 mmol) of iodine to give 1.21 g of the title compound after recrystallization from isopropanol, mp 163-165° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06001863 |
| Quelldatensatz | uspto-grants-1999_12 |
| ORD ID | ord-ac8c9d19226746ccb45e2f5e57ec8ad1 |
| Quellennotiz | uspto-grants-1999_12 |