HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N-(Phenylmethyl)thiourea → N-benzyl-4-(pyridin-2-yl)thiazol-2-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N-(Phenylmethyl)thiourea | HCID 737375 | — |
| Edukt | 2-Bromo-1-(2-pyridinyl)-1-ethanone hydrobromide | HCID 2776231 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | N-benzyl-4-(pyridin-2-yl)thiazol-2-amine | HCID 2902584 | — |
Reaktionsschritte
A solution of 2-(Bromoacetyl)pyridine hydrobromide (100 mg, 0.36 mmol) in ethanol (2 mL) was treated with 1-benzyl-2-thiourea (90 mg, 0.54 mmol). The resulting yellow solution was concentrated, and the crude residue was purified on reverse phase HPLC to produce N-benzyl-4-(pyridin-2-yl)thiazol-2-amine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09321761B2 |
| Quelldatensatz | uspto-grants-2016_04 |
| ORD ID | ord-12ad8a3d918842789af2cb1dad38d843 |
| Quellennotiz | uspto-grants-2016_04 |