HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 642747Erstellt: 24. Oktober 2026
Potassium Phosphate, Tribasic → 1-(3-Chloro-4-cyano-2-methylphenyl)-2-oxo-octahydrocyclopenta[b]-pyrrol-4-yl benzoate
https://huagongshe.com/de/reaction/642747
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Edukt | 2-Chloro-4-iodo-3-methylbenzonitrile | HCID 16731995 | — |
| Edukt | 1-Oxo-octahydrocyclopenta[c]pyrrol-4-yl benzoate | HCID 59259560 | — |
| Edukt | 2-Oxo-octahydrocyclopenta[b]pyrrol-4-yl benzoate | HCID 59259571 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 1-(3-Chloro-4-cyano-2-methylphenyl)-2-oxo-octahydrocyclopenta[b]-pyrrol-4-yl benzoate | HCID 59259566 | — |
| Produkt | 2-(3-Chloro-4-cyano-2-methylphenyl)-1-oxo-octahydrocyclopenta[c]-pyrrol-4-yl benzoate | HCID 59259573 | — |
Reaktionsschritte
To a vial containing mixtures of compound 1I and 1J (100 mg, 0.4 mmol) obtained from previous step in dioxane (1 mL) were added CuI (15.6 mg, 0.08 mmol), K3PO4 (174 mg, 0.82 mmol), 1,2-cyclohexyldiamine (4.7 mg, 0.08 mmol) and compound 1E (136 mg, 0.49 mmol). The vial was sealed, and heated at 110° C. for 14 hr, cooled to RT. The solid was filtered off, and filtrate was concentrated. Purification by silica gel chromatography (5% to 100% EtOAc in hexanes, then 10% methanol in EtOAc) provide the mixtures of title compounds 1K and 1L (total 98 mg) as a yellow oil. MS (ES) m/z 395 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07696241B2 |
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| Quelldatensatz | uspto-grants-2010_04 |
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| ORD ID | ord-722b3a5356f24a2ab6d966e77bcf9ecd |
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| Quellennotiz | uspto-grants-2010_04 |
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