4-(1-Benzylpiperidin-4-yl)morpholine → 4-Morpholinopiperidine

Beteiligte Stoffe

Reaktionsschritte

41.59 g (0.16 Mol) 4-[1-(phenylmethyl)-4-piperidinyl]-morpholine (N) are dissolved in 400 mL methanol, combined with 5.2 g palladium on activated charcoal (10%) and hydrogenated for 18 hours at ambient temperature with 50 psi hydrogen. The catalyst is filtered off and the filtrate is evaporated down. A colourless oil remains, which crystallises after a short time.

Herkunft & Nachweise