Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sulfanilamide | HCID 5333 | — |
| Edukt | Chlorotrimethylsilane | HCID 6397 | — |
| Edukt | 2-chloro-N-(1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | HCID 86628035 | — |
| Lösungsmittel | 1-Butanol | HCID 263 | — |
| Produkt | HCID 68579482 | HCID 68579482 | 56,3% |
Reaktionsschritte
A mixture of 2-chloro-N-(1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (150 mg, 0.34 mmol), sulfanilamide (125 mg, 0.73 mmol) and trimethylsilyl chloride (TMSCl) (0.100 mL, 0.79 mmol) inn-butyl alcohol (4 mL) was heated at 116° C. for 96 h. The mixture was then purified by HPLC to give 4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzenesulfonamide (110 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07705004B2 |
|---|
| Quelldatensatz | uspto-grants-2010_04 |
|---|
| ORD ID | ord-f6a5d8a5e86a40c593b6ebf333a30396 |
|---|
| Quellennotiz | uspto-grants-2010_04 |
|---|
