1-Methylpiperazine → cis-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanone

Beteiligte Stoffe

Reaktionsschritte

cis-4-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 20) was reacted with 1-methyl-piperazine (Aldrich) to give cis-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanone in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C32H37N6O2Cl2 [(M+H)+] 595.2350, observed 595.2351.

Herkunft & Nachweise