HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(S)-1-benzyloxycarbonyl-N-[3-(2-oxo-pyrrolidinyl)propyl]-2-pyrrolidine carboxamide → (S)-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-2-pyrrolidinecarboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (S)-1-benzyloxycarbonyl-N-[3-(2-oxo-pyrrolidinyl)propyl]-2-pyrrolidine carboxamide | HCID 18601121 | — |
| Katalysator | HCID 178418390 | HCID 178418390 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | (S)-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-2-pyrrolidinecarboxamide | HCID 53958674 | 71,9% |
Reaktionsschritte
In 150 ml of methanol was dissolved 4.32 g of compound (99) and the compound was hydrogenated using 432 mg of 10% palladium-carbon as a catalyst. Then, the catalyst was filtered off from the reaction mixture and the filtrate was concentrated to provide 1.99 g of (S)-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-2-pyrrolidinecarboxamide (100).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04610821 |
| Quelldatensatz | uspto-grants-1986_09 |
| ORD ID | ord-37847be760b44289aa15024163438b1d |
| Quellennotiz | uspto-grants-1986_09 |