HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Aminobenzoic Acid → 4-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Aminobenzoic Acid | HCID 978 | — |
| Edukt | Ethyl 4-chloro-7-(trifluoromethyl)quinoline-3-carboxylate | HCID 14515676 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 4-[[3-Ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride | HCID 13825035 | 61,1% |
Reaktionsschritte
A mixture of ethyl 4-chloro-7-(trifluoromethyl)-3-quinoline-carboxylate (3.04 g) and 4-aminobenzoic acid (1.37 g) in tetrahydrofuran (53 ml) was stirred under reflux for 10 hours and cooled to room temperature. The precipitates were collected and washed with tetrahydrofuran to give 4-[[3-ethoxycarbonyl-7-(trifluoromethyl)-4-quinolyl]amino]benzoic acid hydrochloride (2.69 g) as yellow powder.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04735952 |
| Quelldatensatz | uspto-grants-1988_04 |
| ORD ID | ord-bebe478147bd4c42b33c1475c46188a7 |
| Quellennotiz | uspto-grants-1988_04 |