HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 650103Erstellt: 24. Oktober 2026
1-Chloro-2-(isocyanatomethyl)benzene → N-(2-Hydroxy-4-cyanophenyl)N'-(2-chlorobenzyl)urea
https://huagongshe.com/de/reaction/650103
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1-Chloro-2-(isocyanatomethyl)benzene | HCID 2733367 | — |
| Edukt | 4-Amino-3-hydroxybenzonitrile | HCID 10197719 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | N-(2-Hydroxy-4-cyanophenyl)N'-(2-chlorobenzyl)urea | HCID 21714412 | 58,8% |
Reaktionsschritte
To a solution of 2-chlorobenzylisocyanate (125.6 mg, 0.75 mmol) in DMF (1.0 ml), 2-hydroxy-4-cyanoaniline (100 mg, 0.75 mmol) was added. The reaction mixture was stirred at 80° C. for 16 hours. Chromatography of the resulting liquid on silica gel (50% Ethyl acetate/Hexane) gave desired product (80 mg, 58.8%). EI-MS m/z 302.8 (M+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06271261B1 |
|---|
| Quelldatensatz | uspto-grants-2001_08 |
|---|
| ORD ID | ord-a28e45464f8b4e359c7ab98f98b4f3f1 |
|---|
| Quellennotiz | uspto-grants-2001_08 |
|---|
