3-Ethoxy-2-methylacrylaldehyde → Methyl 3-(5-methylpyrimidin-2-yl)benzoate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

2.41 g (10 mmol) of methyl 3-carbamimidoylbenzoate acetate are suspended in 40 ml of methanol, 1.31 ml (11 mmol) of 3-ethoxymethacrolein and 2.04 ml of 30% sodium methoxide in methanol are added, and the mixture is stirred at 50° C. for 15 h. The reaction mixture is evaporated to dryness, and 100 ml of water are added. The precipitate formed is filtered off with suction and dried in vacuo. The crude product is reacted further without further purification; product: 1.65 g; ESI: 229 (M+H).

Herkunft & Nachweise