HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(2-Bromoethyl)-2-chlorobenzene → 1-(2-chlorophenethyl)-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(2-Bromoethyl)-2-chlorobenzene | HCID 2756963 | — |
| Edukt | 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione | HCID 57422424 | — |
| Produkt | 1-(2-chlorophenethyl)-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione | HCID 57944977 | 25% |
Reaktionsschritte
Prepared as in example 10-52 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and 2-chlorophenethyl bromide. Yield: 25%. MS M+H calculated 414.13; found 414.2. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.25 μM.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08076491B2 |
| Quelldatensatz | uspto-grants-2011_12 |
| ORD ID | ord-53cef7aaebff425892bdb60466af0b64 |
| Quellennotiz | uspto-grants-2011_12 |