HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(2-Chloroethyl)-4-methoxybenzoyl chloride → 2-[4-(3-Dimethylamino-pyrrolidin-1-yl)-phenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(2-Chloroethyl)-4-methoxybenzoyl chloride | HCID 12401186 | — |
| Edukt | 1-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine | HCID 21916591 | — |
| Produkt | 2-[4-(3-Dimethylamino-pyrrolidin-1-yl)-phenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one | HCID 68990183 | — |
Reaktionsschritte
According to Method A, [1-(4-amino-phenyl)-pyrrolidin-3-yl]-dimethylamine was reacted with 2-(2-chloroethyl)-4-methoxy-benzoyl chloride. The dihydroisoquinolinone thus obtained was treated with hydrogen bromide according to Method L. In this way the product was obtained with molecular weight 351.45 (C21H25N3O2); MS (ESI): 352 (M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822495B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-bad02b3ce75f4bcaa524b9d91d21c98a |
| Quellennotiz | uspto-grants-2014_09 |