HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Amino-6-bromopicolinic acid → (R)-3-amino-6-bromo-N-(4-(3-(tert-butyldimethyl-silyloxy)piperidin-1-yl)pyridin-3-yl)picolinamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Amino-6-bromopicolinic acid | HCID 45480452 | — |
| Edukt | tert-butyl(R)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine | HCID 86669195 | — |
| Produkt | (R)-3-amino-6-bromo-N-(4-(3-(tert-butyldimethyl-silyloxy)piperidin-1-yl)pyridin-3-yl)picolinamide | HCID 86669194 | — |
Reaktionsschritte
Following Method 11 of Example 305, tert-butyl (R)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine was coupled to 3-amino-6-bromopicolinic acid yielding (R)-3-amino-6-bromo-N-(4-(3-(tert-butyldimethyl-silyloxy)piperidin-1-yl)pyridin-3-yl)picolinamide. LCMS (m/z): 506.2 (MH+); LC Rt=4.03 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822497B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-1d76393791c841ea9d174c7a618b9481 |
| Quellennotiz | uspto-grants-2014_09 |