HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Di-tert-butyl dicarbonate → tert-butyl N-[6-chloro-2-(trifluoromethyl)pyrimidin-4-yl]carbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Edukt | 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine | HCID 245271 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Produkt | tert-butyl N-[6-chloro-2-(trifluoromethyl)pyrimidin-4-yl]carbamate | HCID 87669774 | — |
Reaktionsschritte
Method 24 was followed using 6-chloro-2-(trifluoromethyl)pyrimidin-4-amine (1.0 equiv.), BOC2O (1.0 equiv.), and DMAP (cat.) to afford tert-butyl 6-chloro-2-(trifluoromethyl)pyrimidin-4-ylcarbamate in 64%. LCMS (m/z): 298.1 (MH+); LC Rt=4.73 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822497B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-6afc93268c104228859111cfbfd1091d |
| Quellennotiz | uspto-grants-2014_09 |