HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,2-Diaminocyclohexane → (S)-3-(1H-benzo[d]imidazol-6-yl)-4-(biphenyl-4-yl)oxazolidin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,2-Diaminocyclohexane | HCID 4610 | — |
| Edukt | Carbamic acid, ethyl ester | HCID 5641 | — |
| Edukt | Dimethylhydantoin | HCID 6491 | — |
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | p-Vinylbiphenyl | HCID 16883 | — |
| Edukt | Cesium fluoride | HCID 25953 | — |
| Edukt | 4-Iodobenzene-1,2-diamine | HCID 11207049 | — |
| Edukt | 1-((1R)-((2R,4R,5S)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)-4-((1R)-((2R,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)phthalazine | HCID 51003674 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Lösungsmittel | Ethyl orthoformate | HCID 31214 | — |
| Produkt | (S)-3-(1H-benzo[d]imidazol-6-yl)-4-(biphenyl-4-yl)oxazolidin-2-one | HCID 58228985 | — |
Reaktionsschritte
The compound was synthesized starting from 4-vinylbiphenyl (1.55 g 8.6 mmol), ethyl carbamate (2.38 g, 26.7 mmol), 5,5-dimethylimidazolidine-2,4-dione (2.6 g, 13.2 mmol), (DHQ)2PHAL (0.402 g, 0.52 mmol), K2OsO4x2H2O (0.127 g, 0.34 mmol), 0.38 M aqueous NaOH (74 mL, 28 mmol), 4-iodobenzene-1,2-diamine (0.35 g, 1.5 mmol), copper(I) iodide (0.029 g, 0.15 mmol), cesium fluoride (0.456 g, 3 mmol), cyclohexane-1,2-diamine (0.018 mL, 0.15 mmol), triethyl orthoformate (10 ml) as described in method 5.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09173885B2 |
| Quelldatensatz | uspto-grants-2015_11 |
| ORD ID | ord-6e8b76727f1441b5bae2c514cb2acb44 |
| Quellennotiz | uspto-grants-2015_11 |