HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydroxylamine → Tert-butyl 4-(4-[(hydroxyimino)methyl]-1,3-thiazol-2-yl)piperidine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydroxylamine | HCID 787 | — |
| Edukt | tert-Butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate | HCID 7172298 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | Tert-butyl 4-(4-[(hydroxyimino)methyl]-1,3-thiazol-2-yl)piperidine-1-carboxylate | HCID 86657567 | — |
Reaktionsschritte
To a solution of tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate (10.0 g) in ethanol (110 ml) is added dropwise hydroxylamine (50% in water, 2.48 ml). The mixture is heated to reflux for 2 hours. Volatile substances are subsequently removed under reduced pressure. This gives tert-butyl 4-{4-[(hydroxyimino)methyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate (10.5 g, 100%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822693B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-bde58f4a26f74d58935beddfb0bf972f |
| Quellennotiz | uspto-grants-2014_09 |