HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,4-Dichloro-5-fluoropyrimidine → 2-chloro-5-fluoro-N4-[(1H)indol-6-yl]-4-pyrimidineamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| Edukt | 6-Aminoindole | HCID 256096 | — |
| Produkt | 2-chloro-5-fluoro-N4-[(1H)indol-6-yl]-4-pyrimidineamine | HCID 22060459 | — |
Reaktionsschritte
In a like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine and 6-aminoindole were reacted to provide 2-chloro-5-fluoro-N4-[(1H)-indol-6-yl]-4-pyrimidineamine. LCMS: purity: 92%; MS (m/e): 263 (MH+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08822685B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-9e9c43c0721747f8a1ba4d836c00ceb2 |
| Quellennotiz | uspto-grants-2014_09 |