HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 713641Erstellt: 24. Oktober 2026
1-Hydroxybenzotriazole → 3-chloro-N-(6-trifluoromethylpyridin-2-yl)picolinamide
https://huagongshe.com/de/reaction/713641
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Edukt | Sodium Bicarbonate | HCID 516892 | — |
| Edukt | 2-Amino-6-(trifluoromethyl)pyridine | HCID 821024 | — |
| Edukt | 3-Chloropyridine-2-carboxylic acid | HCID 824632 | — |
| Edukt | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Lösungsmittel | Pyridine | HCID 1049 | — |
| Produkt | 3-chloro-N-(6-trifluoromethylpyridin-2-yl)picolinamide | HCID 118113287 | 89,1% |
Reaktionsschritte
A mixture of 0.81 g of 2-amino-6-trifluoromethylpyridine, 0.78 g of 3-chloropicolinic acid, 1.15 g of EDCI hydrochloride, 0.06 g of HOBt and 10 mL of pyridine was stirred at 70° C. for 2 hours. A saturated aqueous sodium bicarbonate solution was poured to the cooled reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure, and the resulting solid was washed with hexane and dried to obtain 1.33 g of 3-chloro-N-(6-trifluoromethylpyridin-2-yl)picolinamide.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US09185910B2 |
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| Quelldatensatz | uspto-grants-2015_11 |
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| ORD ID | ord-135b62c9e8eb46e3957a6bc97a77bb43 |
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| Quellennotiz | uspto-grants-2015_11 |
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