HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Cyanophenylboronic acid → (rac)-4-(8-(3,4-Dimethylphenyl)-8-hydroxy-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| Edukt | (rac)-4-Bromo-8-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroisoquinolin-8-ol | HCID 89846267 | — |
| Produkt | (rac)-4-(8-(3,4-Dimethylphenyl)-8-hydroxy-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile | HCID 71811407 | 79% |
Reaktionsschritte
In analogy to the procedure described for the preparation of example 1, (rac)-4-bromo-8-(3,4-dimethylphenyl)-5,6,7,8-tetrahydroisoquinolin-8-ol (intermediate A-3) was reacted with 4-cyanophenylboronic acid to give the title compound as white powder in 79% yield. MS: 355.2 (M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09187429B2 |
| Quelldatensatz | uspto-grants-2015_11 |
| ORD ID | ord-d5fc4687a2ee40b8b403260ee64fe309 |
| Quellennotiz | uspto-grants-2015_11 |