Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → methyl[(2S)-1-({2-[(3S)-3-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(diphenyl)silyl]oxy}butyl]phenyl}amino)-1-oxo-3,3-diphenylpropan-2-yl]carbamate

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Reaktionsschritte

A mixture of tert-butyl[(2S)-4-(2-aminophenyl)-1-{[tert-butyl(diphenyl)silyl]oxy}butan-2-yl]carbamate (5, 242 mg, 0.466 mmol), N-(methoxycarbonyl)-β-phenyl-L-phenylalanine (6, 225 mg, 0.752 mmol) (or any other suitable carboxylic acid), HATU (318 mg, 0.836 mmol) and DMAP (50 mg, 0.409 mmol) was dissolved in dry Py (2 ml) and the mixture was stirred at room temperature under N2 for 13 h. Quenched with water (0.5 mL), then diluted (DCM), washed with 5% KHSO4 in water, then saturated NaHCO3, dried over MgSO4, filtered and concentrated. Purified through a chromatographic cartridge of silicagel (12 g) eluted with 10% to 30% EtOAc in hexane to give 305 mg (82% yield) of title compound as white foam, MS: m/z=822.2 (MNa+).

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