HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → (E)-methyl 4-(2-nitrophenyl)but-2-enoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester | HCID 17453 | — |
| Edukt | 2-Nitrobenzeneacetaldehyde | HCID 10844764 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | (E)-methyl 4-(2-nitrophenyl)but-2-enoate | HCID 15264372 | — |
| Produkt | (E)-Methyl 4-(2-nitrophenyl)but-3-enoate | HCID 20269937 | — |
Reaktionsbedingungen
| Temperatur | 110 °C |
|---|
Reaktionsschritte
A mixture of 2-(2-nitrophenyl)acetaldehyde (760 mg, 4.6 mmol) and methoxylcarbonylmethylenetriphenylphosphorane (1.5 g, 4.6 mmol) in toluene (10 mL) was heated at 110° C. for 3 hours. The crude material was purified by silica gel column chromatography eluting with hexanes and ethyl acetate (2:1) to afford the title compound along with (E)-methyl 4-(2-nitrophenyl)but-2-enoate.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09187483B2 |
| Quelldatensatz | uspto-grants-2015_11 |
| ORD ID | ord-bde7d12ffb644ed1aa14dc738b1a44a5 |
| Quellennotiz | uspto-grants-2015_11 |