HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triphenylphosphine → 2-Methyl-5-[2-[4-(trifluoromethyl)phenoxy]ethyl]furan
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triphenylphosphine | HCID 11776 | — |
| Edukt | 4-(Trifluoromethyl)phenol | HCID 67874 | — |
| Edukt | Dibenzyl azodicarboxylate | HCID 5387121 | — |
| Edukt | 2-(5-Methylfuran-2-yl)ethan-1-ol | HCID 11062390 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-Methyl-5-[2-[4-(trifluoromethyl)phenoxy]ethyl]furan | HCID 21874907 | 66,5% |
Reaktionsschritte
To a solution of triphenylphosphine (1.56 g, 5.95 mmol) in THF (40 mL) was added DBAD (1,37 g, 5.95 mmol). After 10 min, 4-trifluoromethylphenol (0.964 g, 5.95 mmol) was added. After 10 additional minutes, compound 21A (0.500 g, 3.97 mmol) was added. After 14 h at 25° C., the reaction was concentrated in vacuo and purified by flash chromatography on silica eluting with chloroform to give 0.713 g (44%) of compound 232A as a clear oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07141578B2 |
| Quelldatensatz | uspto-grants-2006_11 |
| ORD ID | ord-51fc584def8f4673823bbd81a5c2553b |
| Quellennotiz | uspto-grants-2006_11 |