HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(5-chloro-2-(3-(3,4-difluorophenoxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride | HCID 66824369 | — |
| Edukt | 5-Chloro-2-(3-(3,4-difluorophenoxy)azetidin-1-yl)nicotinic acid | HCID 67958520 | — |
| Produkt | Methyl 4-(1-(5-chloro-2-(3-(3,4-difluorophenoxy)azetidin-1-yl)nicotinamido)cyclopropyl)benzoate | HCID 67958829 | 38,2% |
Reaktionsschritte
The title compound (D155) (50 mg) was prepared according to the experimental procedure described in Description 144 starting from 5-chloro-2-(3-(3,4-difluorophenoxy)azetidin-1-yl)nicotinic acid (D109) (87 mg, 0.255 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (58.14 mg, 0.255 mmol).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08828987B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-0fe9306e461e4e0cbd1fe167c666f0bc |
| Quellennotiz | uspto-grants-2014_09 |