HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diisopropylethylamine → 4-Chloro-2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 1-(3-Chloropyridin-2-yl)piperazine hydrochloride | HCID 20455074 | — |
| Edukt | 1H-Benzimidazole, 2,7-dichloro-5-(trifluoromethyl)- | HCID 66937336 | — |
| Produkt | 4-Chloro-2-[4-(3-chloropyridin-2-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole | HCID 57835192 | — |
Reaktionsschritte
The reaction of 1-(3-chloropyridin-2-yl)piperazine hydrochloride (99 mg, 0.5 mmol, Example 3b) and 2,4-dichloro-6-trifluoromethyl-1H-benzoimidazole (76 mg, 0.3 mmol, Example 5b) and N,N-diisopropylethylamine (0.17 mL, 1 mmol, Aldrich) under the conditions of Example 3c afforded the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 416 (M+1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07582761B2 |
| Quelldatensatz | uspto-grants-2009_09 |
| ORD ID | ord-251bf48d86f74d24bb1882a57b49aec7 |
| Quellennotiz | uspto-grants-2009_09 |