HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Morpholine → Benzyl (1r)-1-(hydroxymethyl)-3-(4-morpholinyl)-3-oxopropylcarbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Morpholine | HCID 8083 | — |
| Edukt | (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate | HCID 697924 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | Benzyl (1r)-1-(hydroxymethyl)-3-(4-morpholinyl)-3-oxopropylcarbamate | HCID 59186710 | 86% |
Reaktionsschritte
A solution of EXAMPLE 21B (13.5 g, 57.4 mmol) and morpholine (10.0 mL, 115 mmol) in dioxane (100 mL) was stirred at 70° C. for 18 hours. The solution was concentrated and purified by silica gel chromatography eluting with 10% methanol/ethyl acetate to provide the desired product 6.0 g, 86%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07585858B2 |
| Quelldatensatz | uspto-grants-2009_09 |
| ORD ID | ord-bff9c613403b4e95be6fe0c912eb22be |
| Quellennotiz | uspto-grants-2009_09 |