HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Iodide → (6-{[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynylcarbamoyl]-methyl}-indol-1-yl)-acetic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Iodide | HCID 4875 | — |
| Edukt | Ethyl bromoacetate | HCID 7748 | — |
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | 2-(1H-Indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide | HCID 68825664 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | (6-{[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynylcarbamoyl]-methyl}-indol-1-yl)-acetic acid ethyl ester | HCID 68822191 | — |
Reaktionsschritte
In analogy to the procedure described for example 1 b], 2-(1H-indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide was reacted with bromo-acetic acid ethyl ester in the presence of cesium carbonate and potassium iodide in acetonitrile under reflux conditions to give the title compound as off-white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07405236B2 |
| Quelldatensatz | uspto-grants-2008_07 |
| ORD ID | ord-64f3c470e8ab46bf901b8c4e2407e75c |
| Quellennotiz | uspto-grants-2008_07 |