HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ammonia → 4-Bromo-alpha-methylbenzeneethanamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ammonia | HCID 222 | — |
| Edukt | 1-(4-Bromophenyl)propan-2-one | HCID 736332 | — |
| Edukt | HCID 178418361 | HCID 178418361 | — |
| Katalysator | Nickel | HCID 935 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 4-Bromo-alpha-methylbenzeneethanamine | HCID 205668 | — |
Reaktionsschritte
A mixture of 25.0 g (0.12 mol) 4-bromophenylacetone and 400 mL 7N ammonia in MeOH is charged with 1.20 g Raney nickel. The mixture is stirred in an hydrogen atmosphere (15 psi) at r.t. over night. Again 0.6 g Raney nickel are added and the mixture is stirred again for 3.5 h. After complete reaction, the mixture is filtrated. The residue is washed with MeOH and the solvent of the filtrate is removed in vacuo. The crude product is used without further purification.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08835472B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-661299ba129349a0a22d8a2a17ce912b |
| Quellennotiz | uspto-grants-2014_09 |