HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 76172Erstellt: 24. Oktober 2026
Hydrochloric Acid → 1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)propan-2-amine hydrochloride
https://huagongshe.com/de/reaction/76172
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Tert-butyl 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-yl-carbamate | HCID 66611490 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)propan-2-amine hydrochloride | HCID 66610681 | — |
Reaktionsschritte
To 3.30 g (8.70 mmol) tert-butyl 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-yl-carbamate (I60) in 40 mL MeOH are added 20 mL (25 mmol) HCl (1.25M in MeOH). The mixture is stirred at 70° C. for 7 h. The solvent is removed in vacuo and the crude product is triturated with DIPE and dried in normal atmosphere.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08835472B2 |
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| Quelldatensatz | uspto-grants-2014_09 |
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| ORD ID | ord-9977905a0b844ee4aae5f5837004ce90 |
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| Quellennotiz | uspto-grants-2014_09 |
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