HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dichloromethane → Dichloromethane methanol ammonium hydroxide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dichloromethane | HCID 6344 | — |
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | N-(3-ethyl-1-((1-((3R,4R)-3-fluoropiperidin-4-yl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 67259695 | — |
| Edukt | (3R,4R)-tert-butyl 4-(4-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)-1H-pyrazol-1-yl)-3-fluoropiperidine-1-carboxylate | HCID 70814963 | — |
| Produkt | Dichloromethane methanol ammonium hydroxide | HCID 21896990 | — |
| Produkt | N-(3-ethyl-1-((1-((3R,4R)-3-fluoropiperidin-4-yl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 67259695 | — |
Reaktionsschritte
Preparation of N-(3-ethyl-1-((1-((3R,4R)-3-fluoropiperidin-4-yl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide]: To (3R,4R)-tert-butyl 4-(4-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)-1H-pyrazol-1-yl)-3-fluoropiperidine-1-carboxylate (7 mg, 0.01 mmol) in DCM (2 mL) was added TFA (1 mL). The reaction mixture was stirred for 30 minutes, concentrated and silica gel chromatography (DCM/MeOH/NH4OH 10:1:0.1) gave the final product (3 mg). MS (ES+APCI) m/z=487 (M+H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08841455B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-278158b939ea421c9214b502ed029f5d |
| Quellennotiz | uspto-grants-2014_09 |