Oxalyl chloride → Benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate

Beteiligte Stoffe

Reaktionsschritte

Piperidine-1,4-dicarboxylic acid monobenzyl ester (40.2 g, 0.15 mol) in dichloromethane (300 mL) was treated with oxalyl chloride (100 g, 0.79 mol). The reaction mixture was stirred at ambient temperature for 4 hours and the mixture was concentrated to afford crude 4-chlorocarbonyl-piperidine-1-carboxylic acid benzyl ester (43 g), which was used without further purification.

Herkunft & Nachweise