HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Lithium Hydroxide → 3-(3-Benzenesulfonyl-1H-indol-6-yl)-N-hydroxy-acrylamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Lithium Hydroxide | HCID 3939 | — |
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | Triphenylphosphine | HCID 11776 | — |
| Edukt | Diphenyl disulfide | HCID 13436 | — |
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | m-Chloroperbenzoic acid | HCID 70297 | — |
| Edukt | PyBOP | HCID 2724699 | — |
| Edukt | O-(Tetrahydropyran-2-yl)hydroxylamine | HCID 5142091 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 3-(3-Benzenesulfonyl-1H-indol-6-yl)-N-hydroxy-acrylamide | HCID 76035045 | — |
Reaktionsschritte
Compound 24 was synthesized via the route as shown in Scheme 5 above (reagents and conditions: (a) Ph3P═CH—CO2CH3, CH2Cl2; (b) NaH, Ph-S—S-Ph, DMF; (c) MCPBA, CH2Cl2; (d) LiOH, MeOH, H2O; (e) (i) NH2OTHP, PyBOP, NEt3, DMF; (ii) TFA, MeOH).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08846748B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-bb26cdb93aed4d7085b435cf27d4bef9 |
| Quellennotiz | uspto-grants-2014_09 |