HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diisopropylethylamine → (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 2-Bromo-4-fluorobenzonitrile | HCID 118939 | — |
| Edukt | (2R)-2-amino-3-phenylpropanamide | HCID 7000171 | — |
| Lösungsmittel | Dimethyl Sulfoxide | HCID 679 | — |
| Produkt | (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide | HCID 67509091 | 23,3% |
Reaktionsschritte
A solution of 2-bromo-4-fluorobenzonitrile (255 mg, 1.27 mmol), D-phenylalanine amide (220 mg, 1.34 mmol) and DIEA (0.466 mL, 2.68 mmol) in DMSO (3 mL) was stirred at 100 C for 18 h. The mixture was then purified by HPLC to give (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide (102 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08846928B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-e9254a9343a04fa4b0ed05ac1403204f |
| Quellennotiz | uspto-grants-2014_09 |