HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzimidazole → 2-(2-(difluoromethyl)-4-fluorophenyl)-1H-benzo[d]imidazole-4-carboxylic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzimidazole | HCID 5798 | — |
| Edukt | 2,3-Diaminobenzoic acid | HCID 198069 | — |
| Edukt | 2-(Difluoromethyl)-4-fluorobenzaldehyde | HCID 86652255 | — |
| Produkt | 2-(2-(difluoromethyl)-4-fluorophenyl)-1H-benzo[d]imidazole-4-carboxylic acid | HCID 67203026 | — |
Reaktionsschritte
The same general procedure outlined above for the preparation of benzimidazole was used employing 2-(difluoromethyl)-4-fluorobenzaldehyde 45 and 2,3-diaminobenzoic acid 1 as the starting materials to afford 2-(2-(difluoromethyl)-4-fluorophenyl)-1H-benzo[d]imidazole-4-carboxylic acid 46. MS (ESI) calcd for C15H9F3N2O2: 306.6; found: 307 [M+H].
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08846947B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-74fc318cc7de48ce92ab8b4c2f194d8e |
| Quellennotiz | uspto-grants-2014_09 |