Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Venlafaxine | HCID 5656 | — |
| Edukt | 1-Dodecanethiol | HCID 8195 | — |
| Edukt | Sodium Methoxide | HCID 10942334 | — |
| Produkt | Desvenlafaxine | HCID 125017 | — |
Reaktionsschritte
Dodecanethiol (122 g), venlafaxine (111 g), and a methanolic solution of sodium methanolate (30%, 90 g) and PEG 400 are heated to 190° C. The methanol is distilled off and the solution is stirred for 2 hours at 190° C. Then the temperature is lowered, 2-propanol (450 g) is added and the pH is adjusted to 9.5 with aqueous HCl. The precipitate is collected by suction filtration, and the cake is washed with 2-propanol, toluene, 2-propanol and water. The wet O-desmethylvenlafaxine is dried in vacuo.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07154001B2 |
|---|
| Quelldatensatz | uspto-grants-2006_12 |
|---|
| ORD ID | ord-014df8edd2784c42bdd24c0f8e68eb7e |
|---|
| Quellennotiz | uspto-grants-2006_12 |
|---|
