HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochlorothiazide → 2-(2-Bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochlorothiazide | HCID 3639 | — |
| Edukt | 1,2-Dibromoethane | HCID 7839 | — |
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | Benzylbromoacetate | HCID 21881508 | — |
| Produkt | 2-(2-Bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine | HCID 14280971 | — |
Reaktionsschritte
Treat 6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine with Cs2CO3 and substitute 1,2-dibromoethane for benzylbromoacetate in the procedure of Example 7, step A to obtain 2-(2-bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04778795 |
| Quelldatensatz | uspto-grants-1988_10 |
| ORD ID | ord-6b9669262562417cac6d976e2a44bae5 |
| Quellennotiz | uspto-grants-1988_10 |