HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid → Tert-butyl 4-(4-(2-(pyridin-4-yl)thiazole-4-carboxamido)isothiazol-5-yl)piperazine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid | HCID 716091 | — |
| Edukt | 2-(2,6-Difluorophenyl)-1,3-thiazole-4-carboxylic acid | HCID 24278454 | — |
| Edukt | Tert-butyl 4-(4-aminoisothiazol-5-yl)piperazine-1-carboxylate | HCID 86720862 | — |
| Produkt | Tert-butyl 4-(4-(2-(pyridin-4-yl)thiazole-4-carboxamido)isothiazol-5-yl)piperazine-1-carboxylate | HCID 86720861 | 89,3% |
Reaktionsschritte
Following the procedure described in Step (3) of Example 6, and substituting Compounds 2E and 6D8 with 2-(pyridin-4-yl)thiazole-4-carboxylic acid (19E) (58 mg, 0.28 mmol) and tert-butyl 4-(4-aminoisothiazol-5-yl)piperazine-1-carboxylate (31D3) (80 mg, 0.28 mmol) respectively, Compound 31A (120 mg, 0.25 mmol) was obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08969584B2 |
| Quelldatensatz | uspto-grants-2015_03 |
| ORD ID | ord-74bcf30c1b6648f49792e395565db9c8 |
| Quellennotiz | uspto-grants-2015_03 |