5-Amino-2,3-dihydro-isoindol-1-one → (R)-1-((R)-4-(3,5-bis(trifluoromethyl)phenyl)-3-oxomorpholin-2-yl)-2-oxo-2-(1-oxoisoindolin-5-ylamino)ethyl acetate

Beteiligte Stoffe

Reaktionsschritte

According to the Step 70-5 in the synthetic method for EXAMPLE 70, compound 73-3 (65 mg) was used instead of compound 70-4 to couple to 5-aminoisoindolin-1-one (25 mg) to obtain compound 74-1 (69 mg) as a white solid after reverse-phase (C18) purification.

Herkunft & Nachweise