Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 3-Bromopyridine | HCID 12286 | — |
| Edukt | 1,4-Dioxane | HCID 31275 | — |
| Edukt | 3-(Methoxycarbonyl)benzeneboronic acid | HCID 2734714 | — |
| Katalysator | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | Methyl 3-(3-pyridinyl)benzoate | HCID 4133188 | 90% |
Reaktionsschritte
A mixture of (3-(methoxycarbonyl)phenyl)boronic acid (600 mg, 3.33 mmol), 3-bromopyridine (479 mg, 3.0 mmol), K2CO3 (1.2 g, 9.0 mmol) and Pd(dppf)Cl2 (50 mg) in a solution of dioxane (10 mL) and H2O (2.5 mL) was stirred at 120° C. for 30 minutes with microwave heating under N2. The catalyst was then filtered and the filtrate concentrated. The residue was then purified by column chromatography to give the desired product and used directly in the next step. (630 mg Yield 90%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US08993555B2 |
|---|
| Quelldatensatz | uspto-grants-2015_03 |
|---|
| ORD ID | ord-1847187d0eac452281a98d3d17245484 |
|---|
| Quellennotiz | uspto-grants-2015_03 |
|---|
