HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cesium carbonate → {5-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | 5-Chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine | HCID 21935960 | — |
| Edukt | (5-Hydroxy-indol-1-yl)-acetic acid ethyl ester | HCID 57675474 | — |
| Produkt | {5-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester | HCID 69642003 | — |
Reaktionsschritte
In analogy to the procedure described in example 1 h], 5-chloromethyl-4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidine was reacted with (5-hydroxy-indol-1-yl)-acetic acid ethyl ester (example 1 c]) in the presence of cesium carbonate to give {5-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester, which was subsequently treated with lithium hydroxide in analogy to the procedure described in example 1 i] to yield {5-[4-cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethoxy]-indol-1-yl}-acetic acid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06995263B2 |
| Quelldatensatz | uspto-grants-2006_02 |
| ORD ID | ord-4a5f7624697045fba29eb493d67a60c5 |
| Quellennotiz | uspto-grants-2006_02 |