HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Cyanide → Methyl 6-amino-1,3-benzodioxole-5-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Cyanide | HCID 8929 | — |
| Edukt | 6-Nitro-1,3-benzodioxole-5-carboxaldehyde | HCID 12840 | — |
| Edukt | 1,3-Benzodioxole-5-carboxylic acid, 6-nitro-, methyl ester | HCID 69758 | — |
| Katalysator | Palladium | HCID 23938 | — |
| Katalysator | HCID 178418406 | HCID 178418406 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | Methyl 6-amino-1,3-benzodioxole-5-carboxylate | HCID 290838 | — |
Reaktionsschritte
3,4-Methylenedioxy-6-nitrobenzaldehyde is converted to methyl 3,4-methylenedioxy-6-nitrobenzoate in methanol in the presence of sodium cyanide and manganese dioxide (Synthetic Commun., 27(7), 1281–1283 (1997)). Methyl 3,4-methylenedioxy-6-nitrobenzoate is hydrogenated in ethanol in the presence of palladium, 10% on carbon powder, at room temperature and atmospheric pressure to give methyl 3,4-methylenedioxy-6-amino-benzoate.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07002022B2 |
| Quelldatensatz | uspto-grants-2006_02 |
| ORD ID | ord-ceeee743870d4098918b30efb5a143e5 |
| Quellennotiz | uspto-grants-2006_02 |