HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 897207Erstellt: 24. Oktober 2026
Nitrogen → 6-(n-butyl)-4-[1-(3-phenyl-allyl)-piperidine-4-ylamino]-chromen-2-One
https://huagongshe.com/de/reaction/897207
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Nitrogen | HCID 947 | — |
| Edukt | 6-Bromo-4-[1-(3-phenyl-allyl)-piperidine-4-ylamino]-chromen-2-One | HCID 73712352 | — |
| Edukt | HCID 178448256 | HCID 178448256 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Katalysator | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 6-(n-butyl)-4-[1-(3-phenyl-allyl)-piperidine-4-ylamino]-chromen-2-One | HCID 73712353 | 13% |
Reaktionsschritte
Into a dry microwave vial under N2 was added 6-Bromo-4-[1-(3-phenyl-allyl)-piperidine-4-ylamino]-chromen-2-one (20 mg, 0.046 mmol), Pd(dppf)Cl2 (˜5 mol %), and CuI (˜6 mol %) in dry THF (0.5 mL) followed by n-butyl zinc bromide (0.273 mL, 0.138 mmol (0.5M in THF)) dropwise. The solution was heated in the microwave for 10 minutes at 160° C., filtered, and was purified by Prep HPLC to give 2.5 mg (10%) of the desired compound as the TFA salt. MS (ESI(+)Q1MS m/z 417 (M+H)+; 1H NMR (300 MHz, MeOH) δ ppm. 96 (t, 3H), 1.33-1.42 (m, 2H), 1.61-1.69 (m, 2H), 1.91-2.03 (m, 2H), 2.41 (br d, 2H), 2.72 (t, 2H), 3.24 (br t, 2H), 3.73 (br d, 2H), 3.96 (m, 3H), 5.42 (s, 1H), 6.30-6.40 (m, 1H), 6.95 (d, 1H), 7.23-7.54 (m, 8H), 7.86 (d, 1H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06921821B2 |
|---|
| Quelldatensatz | uspto-grants-2005_07 |
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| ORD ID | ord-9a8152a22343432796c7d16df1b85271 |
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| Quellennotiz | uspto-grants-2005_07 |
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