HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 6-Morpholinonicotinoyl Chloride | HCID 2776461 | — |
| Edukt | 5-Chloro-1H-indole-3-ethylamine monohydrochloride | HCID 2827494 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide | HCID 67972953 | 57% |
Reaktionsschritte
N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide was obtained following Method C starting from 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.042 g, 0.178 mmol), 6-morpholinonicotinoyl chloride (0.045 g; 0.178 mmol), and triethylamine (0.062 mL; 0.446 mmol) in dichloromethane (5 mL). Flash chromatography on silica gel (eluent 1 to 10% methanol in dichloromethane) furnished 0.039 g (57%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide as a solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09284271B2 |
| Quelldatensatz | uspto-grants-2016_03 |
| ORD ID | ord-da783714262d4fa3aa320c7d4195c129 |
| Quellennotiz | uspto-grants-2016_03 |