HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3,3-Difluoroazetidine hydrochloride → 2-{[6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3,3-Difluoroazetidine hydrochloride | HCID 2758247 | — |
| Edukt | 2-[(5-Bromo-6-cyclopropylmethoxy-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid ethyl ester | HCID 71087280 | — |
| Produkt | 2-{[6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl ester | HCID 71087467 | — |
Reaktionsschritte
The title compound was synthesized in analogy to the procedure described in Example 69 a, using ethyl 2-(5-bromo-6-(cyclopropylmethoxy)picolinamido)-2-ethylbutanoate (Example 265) and 3,3-difluoroazetidine hydrochloride (CAN 288315-03-7) as starting materials. MS (EI): m/e=426.0 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09290451B2 |
| Quelldatensatz | uspto-grants-2016_03 |
| ORD ID | ord-467a22096d2f4eb98c72d6897f9c1892 |
| Quellennotiz | uspto-grants-2016_03 |